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Sep

30

Two Drugs Targeting DNA Damage Response Show Promise in Ongoing Cancer Trials - Apr, 2022

ddr

Two Drugs Targeting DNA Damage Response Show Promise in Ongoing Cancer Trials - Apr, 2022

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers — ATR inhibitor elimusertib and PARP inhibitor AZD5305 — are safe and clinically beneficial in treating patients with advanced solid tumors. Principal investigator Timothy Yap, M.B.B.S., Ph.D., associate professor of Investigational Cancer Therapeutics, today presented new data from the trials at the American Association for Cancer Research (AACR) Annual Meeting 2022.

Sep

15

WHO Recommends Paxlovid (Nirmatrelvir and Ritonavir) for Patients with Non-Severe COVID-19 at High Risk of Hospitalization

covid-19

WHO Recommends Paxlovid (Nirmatrelvir and Ritonavir) for Patients with Non-Severe COVID-19 at High Risk of Hospitalization

WHO made a strong recommendation for nirmatrelvir and ritonavir, sold under the name Paxlovid, for mild and moderate COVID-19 patients at highest risk of hospital admission, calling it the best therapeutic choice for high-risk patients to date.

Aug

29

UM171: the Molecule that Keeps on Giving

hpscs

UM171: the Molecule that Keeps on Giving

Aug

21

GPCR-mediated β-arrestin activation

hedgehog-pathway

GPCR-mediated β-arrestin activation

G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily-related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. GPCRs utilize trimeric G proteins to transduce information from the extracellular environment and other cells to intracellular signals that modulate cellular responses.

Aug

14

Understanding the Functions of CDC7 and CDK1 in Cell Division Cycles

target-cdk1

Understanding the Functions of CDC7 and CDK1 in Cell Division Cycles

Aug

03

Drug Combo Albuterol-Budesonide Reduces Risk of Asthma Attacks

agonist-of-receptors

Drug Combo Albuterol-Budesonide Reduces Risk of Asthma Attacks

Asthma is a condition in which your airways narrow and swell and may produce extra mucus. This can make breathing difficult and trigger coughing, a whistling sound (wheezing) when you breathe out and shortness of breath. For some people, asthma is a minor nuisance. For others, it can be a major problem that interferes with daily activities and may lead to a life-threatening asthma attack. Asthma is often under-diagnosed and under-treated, particularly in low- and middle-income countries.

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